Mechano-Electric Feedback in the Fish Heart

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Mechano-Electric Feedback in the Fish Heart

BACKGROUND Mechanoelectric feedback (MEF) describes the modulation of electrical activity by mechanical activity. This may occur via the activation of mechanosensitive ion channels (MSCs). MEF has not previously been investigated in fish ventricular tissue even though fish can greatly increase ventricular end diastolic volume during exercise which should therefore provide a powerful mechanical ...

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Mechano-electric feedback.

From humble beginnings, cardiac mechanoelectric transduction or feedback has come of age. The last editorial board (Editor-in-Chief, David Hearse, and concerning the Focussed Issue particularly Associate Editor Michael Shattock) facilitated growth by encouraging the Issue. The present board (Editor-in-Chief, Michiel Janse, and concerning this focussed publication, Associate Editor Tobias Opthof...

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Mechano-electric Feedback and Initiation of Cardiac Arrhythmias

The heart beat is controlled by electrical excitation waves which propagate through the heart and initiate cardiac contraction. Contraction of the heart also affects the process of wave propagation resulting in a complex global feedback phenomenon known as mechanoelectrical feedback (MEF). MEF has been studied in electrophysiology for well over a century and may have both pro-arrhythmic and arr...

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Mechano-electrical feedback.

See article by Nanthakumar et al. [6] (pages 303 –309) perimental animals. Human studies addressing MEF also in this issue. have focussed on unphysiological conditions, such as compression /decompression of the left ventricle during cardiopulmonary bypass surgery [3], transient aortic occlu

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Mechano-electric feedback effects in a three-dimensional (3D) model of the contracting cardiac ventricle

Mechano-electric feedback affects the electrophysiological and mechanical function of the heart and the cellular, tissue, and organ properties. To determine the main factors that contribute to this effect, this study investigated the changes in the action potential characteristics of the ventricle during contraction. A model of stretch-activated channels was incorporated into a three-dimensiona...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2010

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0010548